China National Center for Bioinformation Chinese Academy of Sciences Beijing 100101, China
I graduated from Harbin Medical University in 2021 with a bachelor’s degree in bioinformatics. Currently, I am pursuing a Ph.D. under the guidance of Dr. Shi. Throughout my bachelor’s degree, I primarily focused on data analysis and regulatory network construction. My research interests lie in combining data analysis with experiments to explore the potential function of small RNAs in key biological processes.
Publications
Nat Commun
Maternal diet-induced alterations in uterine fluid sncRNAs compromise preimplantation embryo development and offspring metabolic health
The periconception period is critical for embryo development, pregnancy outcomes, and offspring health. During this stage, oviductal and uterine fluids facilitate embryo-maternal interactions and support early embryonic development. Using PANDORA-seq, we identify a diverse repertoire of small non-coding RNAs in female mouse oviduct fluid and uterine fluid during preimplantation, with tRNA-derived small RNAs and rRNA-derived small RNAs being predominant. Maternal high-fat diet during preimplantation period significantly alters tsRNA and rsRNA expression in oviduct fluid and uterine fluid compared to normal diet, disrupting blastocyst metabolic gene expression. While implantation remained unaffected, these alterations impair mid-gestation embryonic and placental growth, resulting in reduced birth weight and length, as well as metabolic disorders in offspring. Furthermore, transfecting embryos with uterine fluid-derived sncRNAs altered by maternal high-fat diet mimics the in vivo effects. These findings suggest that tsRNAs and rsRNAs in reproductive fluids may reflect maternal metabolic status and transmit dietary information to the early embryo, which might influence pregnancy outcomes and offspring health.
@article{pan2025nc,title={Maternal diet-induced alterations in uterine fluid sncRNAs compromise preimplantation embryo development and offspring metabolic health},author={Pan, Shijia and Zhang, Liwen and Yang, Xinai and Wang, Lumen and Liu, Changze and Zhang, Jia and Yu, Xuemei and Qiao, Simin and Zeng, Ruoyang and Qian, Yu and Tong, Li and Liu, Xinxin and Shi, Junchao and Yan, Lei and Zhang, Ying},journal={Nature Communications},pages={7637},year={2025},month=aug,doi={10.1038/s41467-025-63054-5},publisher={Nature Publishing Group},url={https://www.nature.com/articles/s41467-025-63054-5},}
